Calcitriol is used in hypoparathyroidism to enhance intestinal calcium absorption because PTH-driven activation of vitamin D is reduced.

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Prepare for the Mark Klimek Electrolytes and Endocrine Test. Utilize flashcards, multiple choice questions, and detailed explanations for each query to enhance your understanding. Ace your exam!

Multiple Choice

Calcitriol is used in hypoparathyroidism to enhance intestinal calcium absorption because PTH-driven activation of vitamin D is reduced.

Explanation:
When PTH is low as in hypoparathyroidism, the kidney’s ability to activate vitamin D is reduced, so the gut can’t absorb calcium as well. Calcitriol provides the active form of vitamin D directly, bypassing the need for PTH-driven activation. It binds to receptors in intestinal cells and increases the production of calcium-handling proteins, boosting calcium absorption from the diet. This helps raise serum calcium and alleviate hypocalcemia.

When PTH is low as in hypoparathyroidism, the kidney’s ability to activate vitamin D is reduced, so the gut can’t absorb calcium as well. Calcitriol provides the active form of vitamin D directly, bypassing the need for PTH-driven activation. It binds to receptors in intestinal cells and increases the production of calcium-handling proteins, boosting calcium absorption from the diet. This helps raise serum calcium and alleviate hypocalcemia.

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