Which ketone bodies accumulate in diabetic ketoacidosis?

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Multiple Choice

Which ketone bodies accumulate in diabetic ketoacidosis?

Explanation:
When insulin is absent or insufficient, fat breakdown accelerates and the liver converts the resulting fatty acids into ketone bodies. The two main ketone bodies that accumulate in diabetic ketoacidosis are acetoacetate and beta-hydroxybutyrate. The high NADH environment in this state pushes the pathway toward beta-hydroxybutyrate formation, so both species build up and contribute to the metabolic acidosis. Acetone is produced from acetoacetate and is mainly a volatile byproduct, seen as fruity breath rather than a major contributor to the blood ketone burden.

When insulin is absent or insufficient, fat breakdown accelerates and the liver converts the resulting fatty acids into ketone bodies. The two main ketone bodies that accumulate in diabetic ketoacidosis are acetoacetate and beta-hydroxybutyrate. The high NADH environment in this state pushes the pathway toward beta-hydroxybutyrate formation, so both species build up and contribute to the metabolic acidosis. Acetone is produced from acetoacetate and is mainly a volatile byproduct, seen as fruity breath rather than a major contributor to the blood ketone burden.

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